SSSSRF Research
Genomic Research
Biobank
Collaboration
Sri Sathya Sai Sanjeevani Research Foundation

Advancing Genomic Research
to Prevent Congenital Heart Disease

"The only way to unravel the marvel that is the human heart is to find the One who made it!"

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Total Samples
0
Blood Samples
0
Serum Samples
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Tissue Samples
3
Research Centres
100%
Free Treatment
About SSSSRF

Genomic Research for
a Healthier Childhood

Sri Sathya Sai Sanjeevani Research Foundation (SSSSRF) is a DSIR recognised Scientific and Industrial Research Organization (SIRO) established to pursue research in Congenital Heart Disease (CHD). A charitable foundation (Darpan No. KA/2017/0154544) with 12A & 80G certification.

Vision: "To Understand and Contribute to Life through the pursuit of Advanced Human Genomics Research in Congenital Heart Diseases"

Research Centre Inauguration
Research Centre Inauguration — Palwal, 7th June 2018
Est. 2018

Why CHD Research
Is Urgent in India

Congenital Heart Defects account for 28% of all birth defects and are among the leading causes of infant mortality in India. Investigating the genetic and epigenetic basis of CHD is essential for primary prevention.

9 / 1,000
Live births with CHD in India
2,40,000+
New CHD cases born annually
28%
Of all birth defects are CHDs
Free
All treatment at SSSSRF hospitals

Research Themes

Genetics
01

Genetics

Unravelling the genetic basis of non-syndromic CHD through WGS, exome sequencing and GWAS in diverse Indian populations.

Read more →
Epigenetics
02

Epigenetics

DNA methylation alterations in CHD. Our study reported DNMT3B & DNMT3A down-regulation in CHD cases.

Read more →
Maternal Health
03

Maternal & Child Health

Maternal nutrition and periconceptional factors — metabolic pathways and their molecular impact in CHD.

Read more →

Biobank Dashboard

Data as on 3rd January 2026
0
Blood Samples
0
Serum Samples
0
Tissue Samples
0
Grand Total
Research CentreInitiated BloodSerum TissueCentre Total
Palwal, Haryana
08.06.201813,8369,99285824,686
Kharghar, Navi Mumbai
21.02.20236,8066,2521,97615,034
Atal Nagar, Raipur
03.04.202417,36814,95054432,862
Grand Total38,01031,1943,37872,582
Dr. C. Sreenivas
Dr. C. Sreenivas
Chairman, SSSSRF
Chairman's Message

A Mission of Compassion
and Scientific Inquiry

Dr. C. Sreenivas has been associated with Bhagawan Sri Sathya Sai Baba and His various Service Projects in Healthcare, Education, and Rural Service Initiatives for over 40 years. He has built and run the Sri Sathya Sai Sanjeevani Hospitals — Centres for Child Heart Care — wherein all services are provided Totally Free of Cost to all.

The Foundation shall bring together Scientists, Clinicians, and Public Health Experts to holistically address Mother & Child Health and Congenital Heart Disease.

Events & Gallery

Event

Padmashree Dr. K.M. Cherian visited SSSSRF

Event

Research Team with Prof. Dr. M.S. Valiathan, 2019

Event

3rd IEC Meet, November 2019

Research

Research Activity at Palwal Centre

Get Involved in Our Mission

Donate · Collaborate · Join our research team · Attend training programmes

Home›About›Overview
About

Overview

DSIR Recognised Scientific & Industrial Research Organisation

Sri Sathya Sai Sanjeevani Research Foundation

Sri Sathya Sai Sanjeevani Research Foundation (SSSSRF) is a DSIR recognised Scientific and Industrial Research Organization (SIRO) established with a purpose to pursue research in Congenital Heart Disease (CHD). This is a charitable foundation (Darpan Registration No. KA/2017/0154544) with 12A & 80G certification.

SSSSRF was registered on 22nd March 2018 at Bangalore with its operational research centres inaugurated on 7th June 2018 in Palwal and on 23rd August 2022 in Kharghar, Navi Mumbai. We are also functional at Atal Nagar (Naya Raipur), Chhattisgarh.

The strength of SSSSRF is its collaboration with Sri Sathya Sai Sanjeevani Pediatric Cardiac Hospitals which are dedicated centres for treatment of Congenital Heart Disease. At SSSSRF, we investigate factors impacting incidence of CHD by understanding the genetic and epigenetic basis of CHD.

Our mission: to contribute to societal welfare by achieving 'Healthy Childhood' through prevention of CHD.

Vision

"To Understand and Contribute to Life through the pursuit of Advanced Human Genomics Research in Congenital Heart Diseases"

Mission

To contribute to societal welfare by achieving 'Healthy Childhood' through primary prevention of CHD.

LEGAL STATUS
Registration
22nd March 2018
DSIR Status
SIRO
NITI Aayog
KA/2017/0154544
Tax Exemption
12A & 80G
Nature
Non-commercial, Charitable
Research Centre
Research Lab
Home›About›Governing Board
About

Governing Board

Foundation Leadership

Dr. C. Sreenivas
Chairman

Dr. C. Sreenivas

Dr. C. Sreenivas has been associated with Bhagawan Sri Sathya Sai Baba and His various Service Projects in Healthcare, Education, Drinking Water Supply and Rural Service Initiatives for over 40 years. A selfless worker; he has built and run several Institutions of Service most notably the Sri Sathya Sai Sanjeevani Hospitals — Centres for Child Heart Care, wherein all services are provided Totally Free of Cost to all.

Sri. Madhusudan Sai
Trustee

Sri. Madhusudan Sai

Sri Madhusudan Sai is an educationist, philanthropist and a social entrepreneur who has built and run University, Schools and various Health Projects in India and abroad with all services provided Totally Free of Cost.

Sri. Balasubramanian Athmanathan
Trustee

Sri. Balasubramanian Athmanathan

Sri. Balasubramanian Athmanathan is CEO of Aditya Birla Sun Life Asset Management Company Limited and is actively involved in various social projects in the field of Education, Healthcare and Nutrition.

Home›About›Research Advisory Committee
About

Research Advisory Committee (RAC)

Eminent scientists and clinicians guiding SSSSRF research

Home›Research›Biobank
Research

Biobank

India's National CHD Biorepository

Background

Congenital Heart Defects (CHDs) are amongst the leading causes of infant mortality comprising of 28% of all birth defects. At Sri Sathya Sai Sanjeevani Hospital, diverse spectrum of CHD cases from all religions, caste and creed are treated totally free of cost. This high magnitude and diversity is an extremely rich resource in CHD research. Invaluable biological samples can be stored systematically in a Biorepository.

Vision

To build national biorepository for CHD in India to aid research towards bringing down the incidence of CHD.

Mission — 1

Build national biorepository for CHD in India.

Mission — 2

Develop skilled manpower in biobanking through training.

Objectives

1

Collect biological samples (blood, serum, plasma, urine, saliva, buccal swab) from CHD patients, parents and available relatives.

2

Collect samples from healthy controls including parents and healthy relatives.

3

Compile detailed case history and environmental causal factor data into a registry.

4

Explore sample storage aspects with scientific significance for efficient QA-QC measures.

5

National capacity building in CHD research through training and services.

6

Spread awareness about the importance, need and science of Biobanking in India.

Facilities

🧊 −80°C Freezers
🧊 −20°C Freezers
🧊 Portable Liquid Nitrogen Cans (Snap Freezing)
Home›Research›Themes
Research

Research Themes

Three primary themes addressing the aetiology of Congenital Heart Disease

01
🧬

Genetics

Genetic variations contributing to the development of CHD have been explored extensively and present from complex polygenic to simple monogenic high-impact models. The genetic mutations responsible for CHD can be sporadic or familial. Chromosomal abnormalities also contribute to significant cases of CHD.

The genetics of CHD is heterogenous and has been explored for decades, now developing swiftly with advances in genetic technologies. Familial CHDs can present as autosomal recessive, autosomal dominant, or X-linked traits, with the latter mostly attributed to de novo mutations.

At SSSSRF, we are engaged in unravelling the genetic basis primarily of non-syndromic CHD.

Genetics
Epigenetics
02
🔬

Epigenetics

Heart is the first organ to develop during embryogenesis. Towards this development, there is coordinated and precise expression of several genes — morphogens, transcription factors, epigenetic regulators and cardiac genes — forming a complex regulatory network during early heart development.

Epigenetic errors can lead to abnormal cardiac development during fetal life. At SSSSRF, we focus on DNA methylation alterations in CHD susceptible to environmental factors. Our study reported down-regulation of DNMT3B and DNMT3A in CHD cases.

03
👶

Maternal & Child Health

"You are what your mother had eaten when you were in the womb!" Mother's health and periconceptional nutrition shape the lifetime of the offspring. DNA methylation is nutrition-dependent and adverse changes in maternal nutrition during conception can lead to structural malformations in the growing embryo.

We at SSSSRF are working on maternal nutrition and its role in CHD. The integrated approach involves study of metabolic pathways, metabolic markers and the resultant impact at the molecular level.

Maternal Health
Home›Research›Groups
Research

Research Centre Groups

Three active research centres across India

Palwal, Haryana

Flagship Research Centre
Est. 7th June 2018
13,836
Blood
9,992
Serum
858
Tissue
24,686
Total
Principal Investigator
Dr. Soma Guhathakurta
Dr. Soma Guhathakurta
Senior Consultant, Paediatric Cardiac Research
MBBS, MS, MCh · R.G. Kar Medical College | PhD · IIT Madras
Team Members
D
Dr. Prachi Kukshal
Scientist · PhD Zoology
S
Mr. Shadab Ahmed
Research Officer · Btech, PG Diploma Agri-Biotech
A
Mr. Ajay Kumar
Senior Lab Technologist · BA, Diploma (OT)
CONTACT & ADDRESS
Address
In the premises of Sri Sathya Sai Sanjeevani International Centre for Child Heart Care & Research, Baghola, NH-2, Delhi-Mathura Road, Palwal (District), Haryana – 121102
Phone
01275 298130
Email
palwal@ssssrf.org
Hours
Monday – Saturday, 9am to 5pm
Directions

Located on Delhi-Mathura Highway (NH2). Nearest city: Faridabad. Nearest airport: Indira Gandhi International Airport, New Delhi.

Home›Research›Publications
Research

Publications

Peer-reviewed research from Sri Sathya Sai Sanjeevani Research Foundation

01
2022

Joshi RO, Kukshal P, Chellappan S, Guhathakurta S. The study of expression levels of DNA methylation regulators in patients affected with congenital heart defects (CHDs). Birth Defects Research. 2022;1–10.

Birth Defects Research
02
2021

Chellappan S, Manohar K, Sathe Y, James A, Joshi R, Hamza A. Pseudoaneurysm following a neonatal coarctation repair; a dreadful complication. Asian Cardiovascular & Thoracic Annals 2021;1–7.

Asian Cardiovascular & Thoracic Annals
03
2021

Chellappan S, Manohar K, Sathe Y, Amboli S, Joshi R, Hiremath N. Isolated left subclavian with a compensatory ductus in a child with Tetralogy of Fallot. Asian Cardiovascular & Thoracic Annals 2021;0(0):1–3.

Asian Cardiovascular & Thoracic Annals
04
2021

Chellappan S, Manohar K, Sathe Y, Pandey R, Joshi R, Deshpande A. Acyanotic Truncus Arteriosus: Not a Misnomer But a True Rarity. World Journal of Paediatric and Congenital Heart Surgery; DOI: 10.1177/21501351211000367.

World J Paediatric & Congenital Heart Surgery
05
2020

Joshi RO, Chellappan S, Kukshal P. Exploring the Role of Maternal Nutritional Epigenetics in Congenital Heart Disease. Curr Dev Nutr 2020;4:nzaa166.

Current Developments in Nutrition
06
2020

Chellappan S, Soman KR, Sathe Y, Kukshal P, James A. Transesophageal Echocardiography Reveals a Missed Right Atrial Aneurysm in a Patient with Atrial Septal Defect and Mitral Valve Prolapse. J Cardiovasc Echogr. 2020 Jul-Sep;30(3):171-173.

Journal of Cardiovascular Echography

For the complete publication list, contact the research team.

Request Full List →
Home›Research›Collaborations
Research

Collaborations

National and international research partnerships

Sri Sathya Sai Sanjeevani Hospital

Primary clinical partner providing CHD patient access for all research programmes. All treatment totally free of cost.

Sri Sathya Sai University for Human Excellence

Academic collaboration for research training and scientific development.

D Y Patil University School of Medicine

Medical research collaboration for clinical studies and academic programmes.

Rajiv Gandhi Centre for Biotechnology

Biotechnology and genomics research collaboration, Dept. of Biotechnology, Govt. of India.

ACTREC

Translational research collaboration in cancer biology and genomics.

National University of Singapore

International genomics and advanced research collaboration.

IDRS Labs Pvt. Ltd.

Diagnostics and laboratory science collaboration for sample analysis.

Research Collaborations Open

We are open for research collaborations. Contact: info@ssssrf.org

Home›Research›Training
Research

Training

Research training at Palwal and Kharghar in Genomics & Molecular Biology

2–3 Months

Short-term Course

Desired Qualification

Undergraduate in Life Science / Biotechnology / Botany / Zoology or Diploma in Medical Laboratory Technology.

Hands-on experience in genomics and molecular biology laboratory techniques.

6 Months

Dissertation Course

Desired Qualification

Masters in Life Science / Biotechnology.

Post-graduate dissertation research in CHD genomics and molecular biology at SSSSRF.

How to Apply

Applications can be sent to the Laboratory in charge throughout the year. There will be an initial scrutiny by selection committee and shortlisted candidates will be called for personal interview.

Write to: researchcentre@srisathyasaisanjeevani.com — upload your CV along with your area of interest.

Apply for Training →
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Updates

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Home›Events
Gallery

Events

Research activities, visits and events at SSSSRF

Event

Padmashree Dr. K.M. Cherian visited SSSSRF

Event

Research Team with Prof. Dr. M.S. Valiathan, 2nd November 2019

Event

3rd Institutional Ethics Committee Meet, 15th November 2019

Event

Research Event

Event

Research Event

Event

Research Event

Event

Research Event

Inauguration

Research Centre Inauguration, Palwal, 7th June 2018

Research

Research Activity at Palwal Centre

Research

Research Activity

Research

Research Activity

Research Lab

Research Laboratory

Home›Contact
Connect

Contact

Research centres open Monday – Saturday, 9am to 5pm

For General / Career enquiries: info@ssssrf.org

PALWAL, HARYANA

In the premises of Sri Sathya Sai Sanjeevani International Centre for Child Heart Care & Research, Baghola, NH-2, Delhi-Mathura Road, Palwal (District), Haryana – 121102

📞 01275 298130
📧 palwal@ssssrf.org
Directions

Located on Delhi-Mathura Highway (NH2). Nearest city: Faridabad. Nearest airport: IGI Airport, New Delhi.

NAVI MUMBAI, MAHARASHTRA

In the premises of Sri Sathya Sai Sanjeevani Centre, Plot No. 2, Sector 38, Kharghar, Navi Mumbai, Maharashtra 410210

📞 +02220870211 / +02220870411
📧 kharghar@ssssrf.org
Directions

8 km from Kharghar railway station. 41 km from Chhatrapati Shivaji International Airport, Mumbai.

RAIPUR, CHHATTISGARH

In the premises of Sri Sathya Sai Sanjeevani Center for Child Heart Care, Sector 2, Atal Nagar (Naya Raipur), Chhattisgarh – 492101

📞 07712970325
📧 raipur@ssssrf.org
Directions

~26 km from Raipur Railway Station, 11 km from airport. Landmark: International Cricket Stadium, Atal Nagar.

Home›Get Involved
Get Involved

Join Our Mission

Donate · Collaborate · Career · Training · Research

How You Can Be Part of SSSSRF

Your support — in any form — advances our mission of preventing Congenital Heart Disease through genomic research.

💰

Donate

Fund genomic research that saves children's lives. 80G tax exemption available for Indian donors. FCRA registered for international donors.

🤝

Research Collaboration

We welcome collaboration proposals from scientists and research institutions nationally and internationally.

💼

Career Avenues

Join our research team as a scientist, clinician, or support staff. Current opening: Bioinformatician at Palwal.

🎓

Training Programmes

Short-term (2–3 months) and dissertation (6 months) training in Genomics & Molecular Biology at Palwal and Kharghar.

Donate

Support Research That
Changes Lives

All treatment at SSSSRF-linked hospitals is provided Totally Free of Cost. Your donation directly funds genomic research to prevent CHD. Indian donors receive 80G tax exemption.

📧 getinvolved@ssssrf.org
Donate Now →
SSSSRF Mission
Home›Get Involved›Donate
Get Involved

Donate

Fund genomic research that prevents Congenital Heart Disease

Why Donate?

All treatment at Sri Sathya Sai Sanjeevani Hospitals is provided Totally Free of Cost to every patient. Your donation funds cutting-edge genomic research to understand and prevent CHD.

Indian donors are eligible for tax exemption under Section 80G of the Income Tax Act. We are also FCRA registered for international donations.

How to Contribute

To contribute, kindly contact us at:

getinvolved@ssssrf.org
Contact Us to Donate →
"Healthcare is complete when treatment of disease is accompanied by the understanding of its causes."
— SSSSRF
Home›Get Involved›Be Part of Research
Get Involved

Be a Part of Research

Open for research collaborations nationally and internationally

Research Collaboration

We welcome collaboration proposals from scientists and research institutions nationally and internationally. Write to us with your proposal and areas of synergy.

info@ssssrf.org
Write to Us →

Upload CV & Apply

Interested in joining the SSSSRF team? Upload your CV along with a brief statement of your research interest.

researchcentre@srisathyasaisanjeevani.com
Send CV →
Home›Get Involved›Career Avenues
Get Involved

Career Avenues

Current openings at SSSSRF

Latest Opening

Open

Bioinformatician

One PostPalwal, Haryana
Desired Qualification

First-class postgraduate degree or equivalent in Bioinformatics / Biotechnology / Computational Biology / Life Sciences.

Preferred Experience
  • 1–2 years experience in next-generation sequencing, preferably whole-exome sequencing data analysis.
  • Knowledge of bioinformatics tools and basic statistical analysis.
Send CV to
hr.palwal@ssssrf.org
Apply Now →

General Applications

Write to info@ssssrf.org or hr.palwal@ssssrf.org with your CV and brief statement of interest.

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